Director’s Research
EMBL
Meyerhofstrasse 1
D-69117 Heidelberg
Germany

Phone: +49-6221-387-8145
Fax: +49-6221-387-8518
email: ferring@embl.de

Characterization of IRP 1 and 2 knock-out Mice

Together with Bruno I analyze IRP1 and 2 K.O. mice looking for phenotypic changes in the body due to the lack of these proteins…

Publications

Galy B, Ferring-Appel D, Becker C, Gretz N, Gröne HJ, Schümann K, Hentze MW (2013). Iron regulatory proteins control a mucosal block to intestinal iron absorption. Cell Rep. 2013 Mar 28;3(3):844-57. doi: 10.1016/j.celrep.2013.02.026. Epub 2013 Mar 21.

Galy, B., Ferring-Appel, D., Sauer, S.W., Kaden, S., Lyoumi, S., Puy, H., Kolker, S., Grone, H.J. & Hentze (2010), Iron regulatory proteins secure mitochondrial iron sufficiency and function. M.W. Cell Metab. Aug 4;12(2):194-201.

Ferring-Appel D., M.W. Hentze, B. Galy (2009) Cell autonomous and systemic context-dependent functions of iron regulatory protein 2 (IRP2) in mammalian iron homeostasis. Blood. 113:679-687

Galy B., D. Ferring-Appel, S. Kaden, H.J. Gröne, and M.W. Hentze (2008) Iron regulatory proteins are essential for intestinal function and control key iron absorption molecules in the duodenum. Cell Metab. 7:79-85.

Galy B., S.M. Holter, T. Klopstock, D. Ferring, L. Becker, S. Kaden, W. Wurst, H.J. Grone, and M.W. Hentze. (2006) Iron homeostasis in the brain: complete iron regulatory protein 2 deficiency without symptomatic neurodegeneration in the mouse. Nat Genet. 38:967-969

Galy B., D. Ferring, and M.W. Hentze. (2005a) Generation of conditional alleles of the murine iron regulatory protein (IRP)-1 and -2 genes. Genesis. 43:181-88

Galy B., D. Ferring, B. Minana, O. Bell, H.G. Janser, M. Muckenthaler, K. Schumann, and M.W. Hentze. (2005b) Altered body iron distribution and microcytosis in mice deficient for Iron Regulatory Protein 2 (IRP2). Blood. 106:2580-89

Galy B., D. Ferring, M. Benesova, V. Benes, and M.W. Hentze. (2004) Targeted mutagenesis of the murine IRP1 and IRP2 genes reveals context-dependent RNA processing differences in vivo. RNA. 10:1019-25

Jüschke C, Ferring D, Jansen RP, Seedorf M. (2004) A novel transport pathway for a yeast plasma membrane protein encoded by a localized mRNA. Curr Biol. Mar 9;14(5):406-11.

Kruse C, Jaedicke A, Beaudouin J, Bohl F, Ferring D, Guttler T, Ellenberg J, Jansen RP (2002). Ribonucleoprotein-dependent localization of the yeast class V myosin Myo4p. J Cell Biol. Dec 23;159(6):971-82.

Münchow S, Ferring D, Kahlina K, Jansen RP (2002). Characterization of Candida albicans ASH1 in Saccharomyces cerevisiae. Curr Genet. May;41(2):73-81. Epub 2002 Apr 27.

Böhl F, Kruse C, Frank A, Ferring D, Jansen RP (2000). She2p, a novel RNA-binding protein tethers ASH1 mRNA to the Myo4p myosin motor via She3p. EMBO J. Oct 16;19(20):5514-24.